| Houston, USA | 11/16 20:55 | 28 | [106] Karlovic, Ivo v Christopher O'Connell [128] | 6-7,6-3,6-4 | |
| Houston, USA | 11/15 20:25 | 27 | Alexis Galarneau v Karlovic, Ivo | 6-7,6-7 | |
| Houston, USA | 11/15 16:00 | 26 | [308] Bangoura, Sekou v Karlovic, Ivo [106] | 6-7,6-2,4-6 | |
| Houston, USA | 11/12 22:20 | 25 | Caruana, Liam v Karlovic, Ivo | 5-7,4-6 | |
| Challenger Charlottesville | 10/29 22:05 | 25 | [300] Filip Peliwo v Karlovic, Ivo [101] | 6-1,7-5 | |
| Basel, Switzerland | 10/19 12:00 | 64 | [111] Gojowczyk, Peter v Karlovic, Ivo [87] | 6-2,6-4 | |
| Moscow, Russia | 10/17 19:40 | 26 | [25] Marin Cilic v Karlovic, Ivo [87] | 6-1,7-6 | |
| Moscow, Russia | 10/15 14:10 | 25 | [87] Karlovic, Ivo v Bedene, Aljaz [71] | 6-4,6-7,7-6 | |
| US Open, New York, USA | 08/27 21:45 | 23 | [79] Karlovic, Ivo v Frances Tiafoe [45] | Retired | |
| Cincinnati, USA | 08/12 19:35 | 24 | [80] Karlovic, Ivo v Jan-Lennard Struff [36] | 5-7,6-7 | |
| Cincinnati, USA | 08/11 18:30 | 46 | [73] Kohlschreiber, Philipp v Karlovic, Ivo [81] | 6-7,7-6,4-6 | |
| Cincinnati, USA | 08/10 20:10 | 45 | [81] Karlovic, Ivo v Tennys Sandgren [72] | 4-6,6-4,7-6 | |
| Montreal, Canada | 08/04 17:00 | 46 | Lopez, Feliciano v Karlovic, Ivo | Walkover | |
| Montreal, Canada | 08/03 16:30 | 45 | [115] Evgeny Donskoy v Karlovic, Ivo [80] | 4-6,6-4,6-7 | |
| Washington, USA | 07/29 17:00 | 24 | [124] Fratangelo, Bjorn v Karlovic, Ivo [80] | 6-4,6-7,7-6 | |
| Newport, USA | 07/15 17:55 | 25 | [82] Karlovic, Ivo v Guido Andreozzi [113] | 6-7,6-7 | |
| Wimbledon, London, Great Britain | 07/03 11:20 | 24 | [80] Karlovic, Ivo v Fabbiano, Thomas [89] | 3-6,7-6,3-6,7-6,4-6 | |
| Wimbledon, London, Great Britain | 07/01 13:55 | 23 | [219] Arnaboldi, Andrea v Karlovic, Ivo [80] | 4-6,4-6,6-7 | |
| London, Great Britain | 06/16 11:40 | 164 | [86] Karlovic, Ivo v Ward, James [204] | 6-7,4-6 | |
| London, Great Britain | 06/15 11:00 | 64 | [86] Karlovic, Ivo v Polansky, Peter [131] | 6-3,7-5 | |
| Challenger - Nottingham | 06/14 11:00 | 26 | [148] Evgeny Donskoy v Karlovic, Ivo [86] | 6-3,6-7,7-6 | |
| Challenger - Nottingham | 06/12 15:00 | 25 | [178] Stefano Napolitano v Karlovic, Ivo [86] | 6-7,6-4,3-6 | |
| Challenger - Surbiton | 06/08 09:30 | 27 | [256] Troicki, Viktor v Karlovic, Ivo [94] | 6-2,5-7,7-6 | |
| Challenger - Surbiton | 06/06 16:05 | 26 | [108] Lopez, Feliciano v Karlovic, Ivo [94] | 6-1,6-7,6-7 | |
| Challenger - Surbiton | 06/05 12:20 | 25 | [184] Sugita, Yuichi v Karlovic, Ivo [94] | 6-7,7-6,3-6 | |
| Open de France | 05/30 13:05 | 24 | [69] Jordan Thompson v Karlovic, Ivo [94] | 6-3,6-4,6-7,6-3 | |
| Open de France | 05/28 10:45 | 23 | [94] Karlovic, Ivo v Lopez, Feliciano [108] | 7-6,7-5,6-7,7-5 | |
| ATP - Houston | 04/08 20:00 | 25 | [107] Harrison, Ryan v Karlovic, Ivo [77] | 6-3,6-4 | |
| ATP - Miami | 03/22 00:05 | 23 | [88] Andujar, Pablo v Karlovic, Ivo [76] | 7-6,6-4 | |
| ATP - Indian Wells | 03/14 01:00 | 26 | [89] Karlovic, Ivo v Dominic Thiem [8] | 4-6,3-6 |