Stadium: William Rolland Stadium
| NCAAF | 2022/09/04 00:00 | Southwestern Pirates v California Lutheran | L | 32-31 |
| NCAAF | 2021/09/05 02:00 | California Lutheran v Southwestern Pirates | W | 37-7 |
| NCAAF | 2022/11/06 02:00 | Chapman Panthers v California Lutheran | L | 65-26 |
| NCAAF | 2022/10/30 02:00 | California Lutheran v La Verne Leopards | L | 22-29 |
| NCAAF | 2022/10/23 02:00 | California Lutheran v Pomona Pitzer Sagehens | L | 24-28 |
| NCAAF | 2022/10/15 20:00 | Claremont Mudd Scripps Stags v California Lutheran | L | 41-3 |
| NCAAF | 2022/10/09 02:00 | California Lutheran v Redlands Bulldogs | L | 14-35 |
| NCAAF | 2022/10/02 02:00 | Whittier Poets v California Lutheran | W | 0-45 |
| NCAAF | 2022/09/24 19:00 | Pacific Lutheran Lutes v California Lutheran | W | 14-17 |
| NCAAF | 2022/09/17 18:00 | California Lutheran v Puget Sound Loggers | W | 35-27 |
| NCAAF | 2022/11/12 19:00 | Sul Ross State Lobos v Southwestern Pirates | L | 44-41 |
| NCAAF | 2022/11/05 18:00 | Southwestern Pirates v Texas Lutheran Bulldogs | L | 17-21 |
| NCAAF | 2022/10/29 18:00 | Austin Kangaroos v Southwestern Pirates | W | 29-40 |
| NCAAF | 2022/10/22 18:00 | Southwestern Pirates v Hardin Simmons Cowboys | L | 0-68 |
| NCAAF | 2022/10/15 19:00 | Howard Payne Yellow Jackets v Southwestern Pirates | L | 48-17 |
| NCAAF | 2022/10/01 23:00 | East Texas Baptist Tigers v Southwestern Pirates | L | 31-10 |
| NCAAF | 2022/09/24 23:00 | Southwestern Pirates v Mcmurry War Hawks | W | 38-33 |
| NCAAF | 2022/09/17 23:00 | Mary Hardin Baylor Crusaders v Southwestern Pirates | L | 68-14 |