Stadium: William B. Greene Jr. Stadium Round: 1
Home Manager: George Quarles Away Manager: Shawn Watson
| NCAAF | 2022/10/29 17:30 | East Tennessee State v Wofford | W | 41-48 |
| NCAAF | 2021/10/02 19:30 | Wofford v East Tennessee State | L | 21-27 |
| NCAAF | 2019/10/05 19:30 | Wofford v East Tennessee State | W | 35-17 |
| NCAAF | 2018/10/20 17:30 | Wofford v East Tennessee State | W | 30-17 |
| NCAAF | 2017/10/28 17:00 | East Tennessee State v Wofford | W | 24-31 |
| NCAAF | 2023/10/07 17:30 | Samford v Wofford | L | 31-10 |
| NCAAF | 2023/09/30 22:00 | Chattanooga v Wofford | L | 23-13 |
| NCAAF | 2023/09/23 17:30 | Wofford v VMI | L | 14-17 |
| NCAAF | 2023/09/16 22:00 | Presbyterian v Wofford | L | 23-20 |
| NCAAF | 2023/09/09 22:00 | Wofford v William & Mary | L | 6-23 |
| NCAAF | 2023/09/02 19:30 | Wofford v Pittsburgh | L | 7-45 |
| NCAAF | 2022/11/19 17:00 | Wofford v Furman | L | 28-63 |
| NCAAF | 2022/11/12 18:30 | VMI v Wofford | W | 16-34 |
| NCAAF | 2023/10/07 19:30 | Mercer v East Tennessee State | L | 24-6 |
| NCAAF | 2023/09/30 17:00 | East Tennessee State v Samford | L | 28-42 |
| NCAAF | 2023/09/16 23:00 | East Tennessee State v Austin Peay | L | 3-63 |
| NCAAF | 2023/09/09 21:30 | East Tennessee State v Carson-Newman Eagles | W | 42-0 |
| NCAAF | 2023/09/02 18:00 | East Tennessee State v Jacksonville State | L | 3-49 |
| NCAAF | 2022/11/19 17:00 | East Tennessee State v Mississippi State | L | 7-56 |
| NCAAF | 2022/11/12 18:00 | Western Carolina v East Tennessee State | L | 20-17 |
| NCAAF | 2022/10/29 17:30 | East Tennessee State v Wofford | L | 41-48 |