Stadium: Burgess-Snow Field at JSU Stadium Round: 1
Home Manager: Rich Rodriguez Away Manager: George Quarles
| NCAAF | 2022/11/19 17:00 | East Tennessee State v Mississippi State | L | 7-56 |
| NCAAF | 2022/11/12 18:00 | Western Carolina v East Tennessee State | L | 20-17 |
| NCAAF | 2022/10/29 17:30 | East Tennessee State v Wofford | L | 41-48 |
| NCAAF | 2022/10/22 19:30 | Samford v East Tennessee State | L | 55-45 |
| NCAAF | 2022/10/15 20:00 | East Tennessee State v Mercer | L | 33-55 |
| NCAAF | 2022/10/08 17:30 | East Tennessee State v VMI | W | 44-21 |
| NCAAF | 2022/10/01 19:00 | Chattanooga v East Tennessee State | L | 24-16 |
| NCAAF | 2022/09/24 16:00 | East Tennessee State v Robert Morris | W | 45-3 |
| NCAAF | 2023/08/26 21:30 | UTEP v Jacksonville State | W | 14-17 |
| NCAAF | 2022/11/19 22:00 | Jacksonville State v Central Arkansas | W | 40-17 |
| NCAAF | 2022/11/12 19:00 | Eastern Kentucky v Jacksonville State | W | 17-42 |
| NCAAF | 2022/10/29 20:00 | Jacksonville State v Austin Peay | W | 40-16 |
| NCAAF | 2022/10/22 18:00 | SE Louisiana v Jacksonville State | L | 31-14 |
| NCAAF | 2022/10/15 23:00 | Jacksonville State v North Alabama Lions | W | 47-31 |
| NCAAF | 2022/10/01 18:00 | Kennesaw State v Jacksonville State | W | 28-35 |
| NCAAF | 2022/09/24 20:00 | Jacksonville State v Nicholls State | W | 52-21 |