Stadium: Alumni Arena
Home Manager: Jim Whitesell Away Manager: Mark Byington
| NCAAB | 2022/11/10 00:00 | Hampton v James Madison | W | 58-106 |
| NCAAB | 2022/11/07 21:00 | Valley Forge Patriots v James Madison | W | 38-123 |
| NCAAB | 2022/02/26 21:00 | Towson v James Madison | L | 95-59 |
| NCAAB | 2022/02/24 00:00 | James Madison v Towson | L | 65-84 |
| NCAAB | 2022/02/20 00:00 | James Madison v UNC Wilmington | L | 77-78 |
| NCAAB | 2022/02/18 00:00 | James Madison v Coll Of Charleston | W | 71-63 |
| NCAAB | 2022/02/15 00:00 | James Madison v Delaware | L | 60-81 |
| NCAAB | 2022/02/12 21:00 | William & Mary v James Madison | W | 55-69 |
| NCAAB | 2022/11/08 00:00 | Colgate v Buffalo | W | 87-88 |
| NCAAB | 2022/03/10 18:30 | Buffalo v Akron | L | 68-70 |
| NCAAB | 2022/03/04 23:00 | Buffalo v Kent State | L | 65-70 |
| NCAAB | 2022/03/02 00:00 | Toledo v Buffalo | L | 92-76 |
| NCAAB | 2022/02/26 19:00 | Northern Illinois v Buffalo | W | 60-70 |
| NCAAB | 2022/02/25 01:00 | Buffalo v Northern Illinois | W | 79-68 |
| NCAAB | 2022/02/23 00:00 | Buffalo v Miami Ohio | W | 86-84 |
| NCAAB | 2022/02/19 21:00 | Western Michigan v Buffalo | W | 73-87 |