Stadium: Wantland Stadium Round: 1
| NCAAF | 2021/11/13 19:00 | Central Missouri Mules v Central Oklahoma | L | 30-29 |
| NCAAF | 2019/10/12 18:30 | Central Missouri Mules v Central Oklahoma | L | 44-26 |
| NCAAF | 2018/10/06 19:00 | Central Oklahoma v Central Missouri Mules | W | 33-26 |
| NCAAF | 2022/11/05 17:00 | Nebraska Kearney v Central Oklahoma | L | 20-18 |
| NCAAF | 2022/10/29 19:00 | Central Oklahoma v Pittsburg State Gorillas | L | 7-38 |
| NCAAF | 2022/10/22 18:00 | Washburn Ichabods Football v Central Oklahoma | L | 37-9 |
| NCAAF | 2022/10/15 19:00 | Central Oklahoma v Fort Hays State University Tigers | W | 35-23 |
| NCAAF | 2022/10/07 00:00 | Central Oklahoma v Northeastern State Riverhawks | W | 55-6 |
| NCAAF | 2022/10/01 19:00 | Blue Tigers v Central Oklahoma | W | 3-45 |
| NCAAF | 2022/09/24 19:00 | Central Oklahoma v Northwest Missouri | W | 23-14 |
| NCAAF | 2022/09/17 22:00 | Missouri Southern Lions v Central Oklahoma | L | 40-21 |
| NCAAF | 2022/11/05 18:00 | Central Missouri Mules v Missouri Western Griffons | W | 40-37 |
| NCAAF | 2022/10/29 18:00 | Central Missouri Mules v Blue Tigers | W | 61-14 |
| NCAAF | 2022/10/22 18:00 | Fort Hays State University Tigers v Central Missouri Mules | L | 27-14 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | W | 20-17 |
| NCAAF | 2022/10/08 18:00 | Emporia State v Central Missouri Mules | L | 44-27 |
| NCAAF | 2022/10/01 18:00 | Central Missouri Mules v Northeastern State Riverhawks | W | 35-13 |
| NCAAF | 2022/09/24 18:00 | Nebraska Kearney v Central Missouri Mules | L | 38-6 |
| NCAAF | 2022/09/17 18:30 | Northwest Missouri v Central Missouri Mules | L | 24-7 |