Stadium: Audrey J. Walton Stadium Round: 1
| NCAAF | 2021/10/30 19:00 | Blue Tigers v Central Missouri Mules | W | 35-77 |
| NCAAF | 2019/11/09 19:00 | Central Missouri Mules v Blue Tigers | W | 73-6 |
| NCAAF | 2022/10/22 18:00 | Fort Hays State University Tigers v Central Missouri Mules | L | 27-14 |
| NCAAF | 2022/10/15 18:30 | Central Missouri Mules v Missouri Southern Lions | W | 20-17 |
| NCAAF | 2022/10/08 18:00 | Emporia State v Central Missouri Mules | L | 44-27 |
| NCAAF | 2022/10/01 18:00 | Central Missouri Mules v Northeastern State Riverhawks | W | 35-13 |
| NCAAF | 2022/09/24 18:00 | Nebraska Kearney v Central Missouri Mules | L | 38-6 |
| NCAAF | 2022/09/17 18:30 | Northwest Missouri v Central Missouri Mules | L | 24-7 |
| NCAAF | 2022/09/09 00:00 | Central Missouri Mules v Washburn Ichabods Football | L | 32-40 |
| NCAAF | 2022/09/02 00:00 | Pittsburg State Gorillas v Central Missouri Mules | L | 21-10 |
| NCAAF | 2022/10/22 19:00 | Blue Tigers v Nebraska Kearney | L | 17-66 |
| NCAAF | 2022/10/15 19:00 | Blue Tigers v Pittsburg State Gorillas | L | 10-49 |
| NCAAF | 2022/10/08 19:00 | Missouri Southern Lions v Blue Tigers | L | 37-14 |
| NCAAF | 2022/10/01 19:00 | Blue Tigers v Central Oklahoma | L | 3-45 |
| NCAAF | 2022/09/24 19:00 | Northeastern State Riverhawks v Blue Tigers | L | 38-10 |
| NCAAF | 2022/09/17 23:00 | Blue Tigers v Fort Hays State University Tigers | L | 14-51 |
| NCAAF | 2022/09/10 19:00 | Blue Tigers v Northwest Missouri | L | 20-58 |
| NCAAF | 2022/09/01 23:00 | Washburn Ichabods Football v Blue Tigers | L | 45-3 |