Stadium: DiSanto Field Round: 1
| NCAAF | 2021/11/13 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | L | 24-6 |
| NCAAF | 2019/11/16 18:00 | Carnegie Mellon Tartans v Case Western Reserve Spartans | L | 24-21 |
| NCAAF | 2018/11/10 22:30 | Case Western Reserve Spartans v Carnegie Mellon Tartans | L | 23-29 |
| NCAAF | 2022/11/05 17:00 | Westminster Titans v Case Western Reserve Spartans | L | 14-13 |
| NCAAF | 2022/10/29 17:00 | Allegheny Gators v Case Western Reserve Spartans | W | 7-54 |
| NCAAF | 2022/10/22 18:00 | Case Western Reserve Spartans v Bethany Bison | W | 45-7 |
| NCAAF | 2022/10/08 17:00 | Case Western Reserve Spartans v Saint Vincent | W | 45-21 |
| NCAAF | 2022/10/01 18:00 | Grove City Wolverines v Case Western Reserve Spartans | L | 14-13 |
| NCAAF | 2022/09/24 23:00 | Geneva Golden Tornadoes v Case Western Reserve Spartans | W | 7-34 |
| NCAAF | 2022/09/17 23:00 | Case Western Reserve Spartans v Washington And Jefferson Presidents | W | 14-10 |
| NCAAF | 2022/09/10 17:00 | Waynesburg Yellow Jackets v Case Western Reserve Spartans | W | 31-45 |
| NCAAF | 2022/10/29 17:00 | Carnegie Mellon Tartans v Saint Vincent | W | 30-12 |
| NCAAF | 2022/10/22 23:00 | Carnegie Mellon Tartans v Geneva Golden Tornadoes | W | 41-0 |
| NCAAF | 2022/10/15 17:00 | Washington And Jefferson Presidents v Carnegie Mellon Tartans | W | 7-12 |
| NCAAF | 2022/10/08 17:00 | Waynesburg Yellow Jackets v Carnegie Mellon Tartans | W | 20-27 |
| NCAAF | 2022/10/01 23:00 | Carnegie Mellon Tartans v Westminster Titans | W | 10-0 |
| NCAAF | 2022/09/24 19:00 | Thiel Tomcats v Carnegie Mellon Tartans | W | 6-35 |
| NCAAF | 2022/09/17 17:00 | Carnegie Mellon Tartans v Grove City Wolverines | W | 40-33 |
| NCAAF | 2022/09/10 17:00 | Rpi Engineers v Carnegie Mellon Tartans | W | 7-10 |