Stadium: Franklin Field Round: 1
Home Manager: Ray Priore Away Manager: Tim Murphy
| NCAAF | 2021/11/13 17:00 | Pennsylvania v Harvard Crimson | W | 7-23 |
| NCAAF | 2019/11/16 17:00 | Pennsylvania v Harvard Crimson | L | 24-20 |
| NCAAF FCS | 2018/11/10 18:00 | Harvard Crimson v Pennsylvania | W | 29-7 |
| NCAAF | 2017/11/11 17:00 | Harvard Crimson v Pennsylvania | L | 6-23 |
| NCAAF | 2022/11/05 17:00 | Columbia Lions v Harvard Crimson | L | 21-20 |
| NCAAF | 2022/10/29 17:30 | Harvard Crimson v Dartmouth Big Green | W | 28-13 |
| NCAAF | 2022/10/21 23:00 | Princeton Tigers v Harvard Crimson | L | 37-10 |
| NCAAF | 2022/10/15 20:00 | Harvard Crimson v Howard | W | 41-25 |
| NCAAF | 2022/10/07 23:00 | Harvard Crimson v Cornell Big Red | W | 35-28 |
| NCAAF | 2022/10/01 17:00 | Holy Cross v Harvard Crimson | L | 30-21 |
| NCAAF | 2022/09/24 16:30 | Harvard Crimson v Brown Bears | W | 35-28 |
| NCAAF | 2022/09/16 23:00 | Merrimack Warriors v Harvard Crimson | W | 21-28 |
| NCAAF | 2022/11/05 17:00 | Pennsylvania v Cornell Big Red | W | 28-21 |
| NCAAF | 2022/10/29 16:30 | Pennsylvania v Brown Bears | L | 31-34 |
| NCAAF | 2022/10/22 17:00 | Yale v Pennsylvania | W | 13-20 |
| NCAAF | 2022/10/15 17:00 | Columbia Lions v Pennsylvania | W | 14-34 |
| NCAAF | 2022/10/08 18:00 | Pennsylvania v Georgetown Hoyas | W | 59-28 |
| NCAAF | 2022/09/30 23:00 | Pennsylvania v Dartmouth Big Green | W | 23-17 |
| NCAAF | 2022/09/24 17:00 | Lafayette v Pennsylvania | W | 0-12 |
| NCAAF | 2022/09/17 17:00 | Colgate v Pennsylvania | W | 14-25 |