Stadium: Five Star Stadium Round: 1
Home Manager: Drew Cronic Away Manager: George Quarles
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | W | 35-38 |
| NCAAF | 2021/04/10 22:00 | East Tennessee State v Mercer | L | 13-21 |
| NCAAF | 2019/11/16 18:00 | Mercer v East Tennessee State | W | 33-38 |
| NCAAF FCS | 2018/11/03 19:00 | East Tennessee State v Mercer | W | 21-18 |
| NCAAF | 2017/09/23 19:30 | East Tennessee State v Mercer | W | 26-23 |
| NCAAF | 2022/10/08 17:30 | East Tennessee State v VMI | W | 44-21 |
| NCAAF | 2022/10/01 19:00 | Chattanooga v East Tennessee State | L | 24-16 |
| NCAAF | 2022/09/24 16:00 | East Tennessee State v Robert Morris | W | 45-3 |
| NCAAF | 2022/09/17 23:30 | Furman v East Tennessee State | L | 27-14 |
| NCAAF | 2022/09/10 20:00 | East Tennessee State v Citadel | L | 17-20 |
| NCAAF | 2022/09/01 23:30 | East Tennessee State v Mars Hill Lions | W | 44-7 |
| NCAAF | 2021/12/11 17:00 | East Tennessee State v DAKOTA DU NORD ETAT DU BISON | L | 3-27 |
| NCAAF | 2021/12/04 19:00 | Kennesaw State v East Tennessee State | W | 31-32 |
| NCAAF | 2022/10/08 20:00 | Western Carolina v Mercer | W | 6-49 |
| NCAAF | 2022/10/01 17:30 | Mercer v Wofford | W | 42-7 |
| NCAAF | 2022/09/24 22:00 | Mercer v Gardner-Webb | W | 45-14 |
| NCAAF | 2022/09/17 22:00 | Citadel v Mercer | W | 0-17 |
| NCAAF | 2022/09/03 23:00 | Mercer v Auburn | L | 16-42 |
| NCAAF | 2022/08/27 23:00 | Morehead State v Mercer | W | 13-63 |
| NCAAF | 2021/11/20 18:00 | Mercer v East Tennessee State | L | 35-38 |
| NCAAF | 2021/11/13 20:00 | Chattanooga v Mercer | W | 6-10 |