Stadium: Memorial Stadium (TX) Round: 1
Home Manager: Todd Whitten Away Manager: Vic Shealy
| NCAAF | 2022/11/12 20:00 | McNeese State v Houston Baptist | L | 21-10 |
| NCAAF | 2022/11/05 19:00 | Houston Baptist v Incarnate Word | L | 20-73 |
| NCAAF | 2022/10/29 19:00 | UT Martin v Houston Baptist | L | 52-28 |
| NCAAF | 2022/10/22 19:00 | Houston Baptist v Texas A&M-Commerce | L | 3-31 |
| NCAAF | 2022/10/15 23:00 | Northwestern State v Houston Baptist | L | 37-10 |
| NCAAF | 2022/10/08 23:00 | Nicholls State v Houston Baptist | L | 19-17 |
| NCAAF | 2022/10/01 20:00 | Houston Baptist v Lamar | W | 37-34 |
| NCAAF | 2022/09/24 23:00 | Houston Baptist v Texas State | L | 0-34 |
| NCAAF | 2022/11/12 20:00 | Tarleton State Texans v Dixie State Trailblazers | L | 28-34 |
| NCAAF | 2022/11/06 00:00 | Abilene Christian v Tarleton State Texans | L | 28-23 |
| NCAAF | 2022/10/30 00:00 | Sam Houston State v Tarleton State Texans | L | 40-21 |
| NCAAF | 2022/10/23 00:00 | Tarleton State Texans v Southwest Baptist | W | 24-10 |
| NCAAF | 2022/10/15 23:00 | Tarleton State Texans v Stephen F. Austin | L | 24-41 |
| NCAAF | 2022/10/09 00:00 | Tarleton State Texans v Southern Utah | W | 42-40 |
| NCAAF | 2022/09/24 23:00 | Tarleton State Texans v North Alabama Lions | W | 43-28 |
| NCAAF | 2022/09/17 23:00 | Tarleton State Texans v Eastern New Mexico | W | 41-6 |