Stadium: Georgetown Stadium Comple Round: 1
| NCAAF | 2019/10/05 18:00 | Southwestern Pirates v Sul Ross State Lobos | L | 9-21 |
| NCAAF | 2018/10/06 23:00 | Sul Ross State Lobos v Southwestern Pirates | W | 7-55 |
| NCAAF | 2021/11/06 18:00 | Texas Lutheran Bulldogs v Southwestern Pirates | W | 14-24 |
| NCAAF | 2021/10/30 18:00 | Southwestern Pirates v Austin Kangaroos | W | 45-19 |
| NCAAF | 2021/10/23 18:00 | Hardin Simmons Cowboys v Southwestern Pirates | L | 69-7 |
| NCAAF | 2021/10/16 18:00 | Southwestern Pirates v Howard Payne Yellow Jackets | L | 17-21 |
| NCAAF | 2021/10/02 23:00 | Southwestern Pirates v East Texas Baptist Tigers | L | 17-27 |
| NCAAF | 2021/09/25 21:00 | Mcmurry War Hawks v Southwestern Pirates | L | 41-31 |
| NCAAF | 2021/09/19 00:00 | Southwestern Pirates v Mary Hardin Baylor Crusaders | L | 3-54 |
| NCAAF | 2021/09/12 00:00 | Belhaven Blazers v Southwestern Pirates | W | 27-34 |
| NCAAF | 2021/11/06 17:00 | Sul Ross State Lobos v East Texas Baptist Tigers | L | 28-31 |
| NCAAF | 2021/10/30 18:00 | Mcmurry War Hawks v Sul Ross State Lobos | W | 11-24 |
| NCAAF | 2021/10/23 18:00 | Sul Ross State Lobos v Mary Hardin Baylor Crusaders | L | 14-72 |
| NCAAF | 2021/10/16 17:00 | Belhaven Blazers v Sul Ross State Lobos | L | 44-0 |
| NCAAF | 2021/10/09 21:00 | Sul Ross State Lobos v North American Stallions | L | 37-44 |
| NCAAF | 2021/10/02 20:30 | Howard Payne Yellow Jackets v Sul Ross State Lobos | L | 73-30 |
| NCAAF | 2021/09/25 23:00 | Sul Ross State Lobos v Texas Lutheran Bulldogs | W | 12-10 |
| NCAAF | 2021/09/18 18:00 | Austin Kangaroos v Sul Ross State Lobos | L | 16-7 |