Stadium: William H. Greene Stadium Round: 1
Home Manager: Larry Scott Away Manager: Trei Oliver
| NCAAF | 2019/11/02 17:00 | N.C. Central v Howard | W | 28-6 |
| NCAAF | 2018/10/06 18:00 | Howard v N.C. Central | W | 35-40 |
| NCAAF | 2017/10/07 17:00 | Howard v N.C. Central | W | 7-13 |
| NCAAF | 2021/11/06 18:00 | Norfolk State v N.C. Central | W | 36-38 |
| NCAAF | 2021/10/30 18:00 | South Carolina State v N.C. Central | L | 27-24 |
| NCAAF | 2021/10/23 17:00 | N.C. Central v Morgan State | W | 28-17 |
| NCAAF | 2021/10/09 18:00 | Tennessee Tech v N.C. Central | L | 27-16 |
| NCAAF | 2021/10/02 20:00 | N.C. Central v Mississippi Valley | L | 16-17 |
| NCAAF | 2021/09/25 22:00 | N.C. Central v North Carolina A&T | L | 14-37 |
| NCAAF | 2021/09/18 22:00 | N.C. Central v Winston-Salem State | W | 20-13 |
| NCAAF | 2021/09/11 22:30 | N.C. Central v Marshall | L | 10-44 |
| NCAAF | 2021/11/06 18:00 | Howard v South Carolina State | L | 12-15 |
| NCAAF | 2021/10/30 18:00 | Howard v Delaware State | L | 23-30 |
| NCAAF | 2021/10/23 17:00 | Norfolk State v Howard | L | 45-31 |
| NCAAF | 2021/10/09 00:00 | Morgan State v Howard | W | 0-27 |
| NCAAF | 2021/10/02 17:00 | Sacred Heart Pion. v Howard | W | 17-22 |
| NCAAF | 2021/09/25 16:00 | Howard v Robert Morris | L | 16-22 |
| NCAAF | 2021/09/18 16:00 | Hampton v Howard | L | 48-32 |
| NCAAF | 2021/09/11 23:30 | Howard v Maryland | L | 0-62 |