Face à face
| Coupe Premier League U23 | 2020/02/25 14:00 | Stoke City v Southampton U21 | L | 4-1 |
| Coupe Premier League U23 | 2019/10/05 14:00 | Southampton U21 v Stoke City | D | 1-1 |
| Angleterre - Premier League 2 | 2019/01/04 19:00 | Southampton U21 v Stoke City | W | 2-0 |
| Angleterre - Premier League 2 | 2018/08/20 18:00 | Stoke City v Southampton U21 | W | 1-4 |
| Angleterre - Premier League 2 | 2018/01/29 19:00 | Stoke City v Southampton U21 | W | 0-2 |
| Angleterre - Premier League 2 | 2017/09/18 18:00 | Southampton U21 v Stoke City | W | 3-0 |
Home History
| Angleterre - Premier League 2 | 2021/09/27 12:30 | Birmingham v Southampton U21 | L | 3-2 |
| Coupe Premier League U23 | 2021/09/23 18:00 | Southampton U21 v West Bromwich U21 | L | 0-6 |
| Angleterre - Premier League 2 | 2021/09/19 13:00 | Southampton U21 v Burnley | L | 0-2 |
| Angleterre - Premier League 2 | 2021/09/10 18:00 | Fulham U21 v Southampton U21 | L | 3-0 |
| Coupe Premier League U23 | 2021/09/02 18:00 | Arsenal FC Reserve v Southampton U21 | D | 1-1 |
| Angleterre - Premier League 2 | 2021/08/29 11:00 | Middlesbrough U21 v Southampton U21 | L | 2-1 |
| Angleterre - Premier League 2 | 2021/08/23 18:00 | Nottingham Forest v Southampton U21 | D | 0-0 |
| Angleterre - Premier League 2 | 2021/08/15 13:00 | Southampton U21 v Norwich City | L | 0-3 |
Away History
| Angleterre - Premier League 2 | 2021/09/27 18:00 | Stoke City v Aston Villa | L | 0-8 |
| Angleterre - Premier League 2 | 2021/09/20 18:00 | Newcastle United v Stoke City | W | 2-3 |
| Angleterre - Premier League 2 | 2021/09/13 18:00 | Middlesbrough U21 v Stoke City | L | 2-0 |
| Coupe Premier League U23 | 2021/09/10 18:00 | Stoke City v Colchester | L | 2-4 |
| Angleterre - Premier League 2 | 2021/08/29 14:00 | Stoke City v Reading U21 | L | 1-2 |
| Angleterre - Premier League 2 | 2021/08/20 18:00 | Norwich City v Stoke City | W | 0-1 |
| Angleterre - Premier League 2 | 2021/08/16 18:00 | Stoke City v Birmingham | W | 2-1 |
| Angleterre - Premier League 2 | 2021/05/17 18:00 | Stoke City v Sunderland | L | 0-2 |